Approximately 3 % of all paragangliomas occur in the head and neck area. Adobe acrobat reader dc software is the free global standard for reliably viewing, printing, and commenting on pdf documents. Paragangliomas are rare extraadrenal neuroendocrine tumors, arising from neural crest precursor cell origin. Find support for a specific problem on the support section of our website. Paragangliomas with their epicentre in the temporal bone and extending into the neck were excluded from the analysis. Pheochromocytoma and paraganglioma treatment pdqpatient. Materials and methods ten patients with 15 paragangliomas were studied with mr imaging. Paraganglia in the head and neck migrate along a branchial mesoderm. Alternatively, you can also download the pdf file directly to your computer, from where it can be opened using a pdf reader. The peripheral nervous system is involved in controlling a variety of body functions including.
Most paragangliomas are either asymptomatic or present as a painless mass. Multiple hnpgs with hepatic paraganglioma are exceedingly rare. The 14 smaller paragangliomas were smooth in contour and demonstrated avid, homogeneous contrast enhancement. Clinical impact of somatostatin receptor scintigraphy in the. Us depicted carotid pgs in all patients evaluated with this modality. Convert files to pdf, compress pdf documents, and share and store your files with adobe acrobat online services. Paraganglioma of seminal vesicle and chromophobe renal.
Pancreatic paragangliomas are rare, and few are malignant. Paragangliomas are rare tumours of the autonomic nervous system and occur in sporadic and hereditary forms. Similar to pheochromocytomas, paragangliomas can secrete catecholamines, although they are usually nonfunctional and clinical presentation is nonspecific. To our knowledge, only 1 other study has examined the natural history of paragangliomas. Paragangliomas, sometimes called glomus tumors, are rare neuroendocrine tumors arising from paraganglia. Pdf paragangliomas are rare autonomic nervous system neuroendocrine tumors deriving from the group of neuroepithelial cells called paraganglion. Typical features include catecholamine overproduction and the potential for. Treatment of head and neck paragangliomas moffitt cancer center. To describe characteristic features of head and neck paragangliomas. Fdm can boost all your downloads up to 10 times, process media files. A case of an orbital paraganglioma, including the first magnetic resonance imaging description of this tumour is described here.
In the head and neck area, most common sites, paragangliomas are mainly found in the carotid body, jugular foramen, the middle ear and vagal glomus. Paragangliomas of the head and neck radiology reference. Paragangliomas that form in the adrenal glands are called pheochromocytomas. The patient underwent surgery with gross total removal of the tumour and relief of his initial chief complaint of visual blurring.
Paraganglioma is a pathological condition in which there is development of a type of tumour in the peripheral nervous system of the body. We report a case of paraganglioma of the duodenum, which emphasizes the necessity to include extraadrenal paraganglioma in the. References to any names, marks, products, or services of third parties or hypertext links to third. Paraganglioma and pheochromocytoma links to information. Paragangliomas of the head and neck are rare, representing jul 17, 2014 paragangliomas are neoplasms that arise from extraadrenal chromaffin cells. Its the only pdf viewer that can open and interact with all types of pdf.
In addition, free download manager for macos and windows allows you to adjust traffic usage, organize downloads, control file priorities for torrents, efficiently download large files and resume broken downloads. Paraganglia are clusters of neuroendocrine cells dispersed throughout the body and closely related to the autonomic nervous system, with either parasympathetic or sympathetic function. Paragangliomas, also called glomus tumors, occur in a variety of places in the head and neck. Sep 25, 2015 paragangliomas pgs are neuroendocrine tumors derived embryonically from the neural crest cells of the autonomic nervous system.
Classification and management of cervical paragangliomas. A hereditary pattern was identified in six patients 9%. Full text views reflects the number of pdf downloads. Extraperitoneal, abdominal paragangliomas most commonly originate from the sympathetic nervous system. Paraganglioma you and your hormones from the society for. Carotid pgs were diagnosed on the basis of us, ct andor mri. If you have problems viewing pdf files, download the latest version of adobe. Just upload files you want to join together, reorder them with draganddrop if you need and click join files. They are also referred to as extraadrenal pheochromocytoma, typically in older literature.
May 01, 2020 if you have problems viewing pdf files, download the latest version of adobe reader. Imaging of head and neck paragangliomas poster no c1754 congress. Free download manager download everything from the internet. Tinnitus, headaches and dysfunction of the cranial nerves are typical symptoms. Oct 30, 2006 paragangliomas are rare tumours of the autonomic nervous system and occur in sporadic and hereditary forms. Group b consisted of 28 patients with known paragangliomas or paraganglioma metastatic lymph node who required staging and assessment of multicentricity. Developing world ent is important as more than 50% of the worlds people live in the developing world. While all contain neurosecretory granules, only in % of cases is secretion of hormones such as catecholamines abundant enough to be clinically significant. A paraganglioma is a type of tumour that arises from the peripheral nervous system part of the nervous system outside the brain and spinal cord, which is further divided into the sympathetic nervous system and the parasympathetic nervous system.
This article is from world journal of surgical oncology, volume 12. A study by langerman et al 3 investigated the growth of 47 cerivcal paragangliomas. Pdf joiner allows you to merge multiple pdf documents and images into a single pdf file, free of charge. Successful management of unsuspected retroperitoneal. The pdf file you selected should load here if your web browser has a pdf reader plugin installed for example, a recent version of adobe acrobat reader. Diagnosis and management of multiple paragangliomas of the. Continuing education modern nuclear imaging for paragangliomas. Paragangliomas of the head and neck region via medica journals.
In some cases, paraganglioma are attributed to certain genetic syndromes affecting other organs of the body. To describe characteristic features of head and neck paragangliomas, for a. All tumors were located within the carotid bifurcation, caused splaying of the internal ica and external carotid arteries eca and had multiple blood vessels with arterial blood flow of lowresistance pattern on doppler study. Pheochromocytoma is a rare tumor that forms in the adrenal medulla the center of the adrenal gland. Paragangliomas are rare, vascular, neuroendocrine tumors that develop in the extraadrenal paraganglion tissue. Paragangliomas of the head and neck jama otolaryngology. The ability of mr to identify the nature and extent of paragan. Pheochromocytoma and paraganglioma are rare tumors that come from the same type of tissue. One of these cases demonstrates metastasis to lymph node, while another case was functional, however, none of these cases showed malignant and large, pancreatic paraganglioma with marked invasion. Of these, 35 patients had 36 vagal paragangliomas and 42 patients had 50 carotid body paragangliomas. If you have problems viewing pdf files, download the latest version of adobe reader. Almost half of all paragangliomas appear in the bone on the side of the headskull temporal bone. However, they cause significant morbidity related to their mass effect. Return to view details about open access atlas of otolaryngology, head and neck operative surgery resection of extratemporal paragangliomas including carotid body and glomus vagale tumours download download pdf.
We present a case of accidental, intraoperatively diagnosed neuroendocrineactive sympathetic paraganglioma, which was suspected and confirmed during elective retroperitoneal. Cancers free fulltext glutaminases as a novel target. Octreotide scintigraphy for the detection of paragangliomas. A gene for hereditary nonchromaffin paragangliomas, a. Familial paragangliomas hereditary cancer in clinical. These tumors are relatively simple and frequently associated with other neurological tumors that develop in embryos.
Any information contained in this pdf file is automatically generated from digital material submitted to epos by third parties in the form of scientific presentations. In case if development of paraganglioma is not associated with any genetic syndrome then it is termed as nonsyndromic paragangliomas. The study was conducted through retrospective analysis of the files of the patients who had undergone surgery with prediagnosis of spinal intradural tumor. Download fulltext pdf case report j evid based med healthc, pissn 2349256 2, eissn 23492570 vol. Sympathetic paragangliomas usually secrete catecholamines and are located in the sympathetic paravertebral ganglia of thorax, abdomen, and pelvis. Dynamic contrast enhancement of paragangliomas of the. Abstractparagangliomas are neoplasms that arise from extraadrenal chromaffin cells. Jansen and colleagues 4 presented volumetric growth data on 20 carotid body tumors, 17 vagal paragangliomas, and 11 jugular paragangliomas. Paragangliomas are rare neuroendocrine tumors that result from the abnormal migration of neural crest progenitor cells, or paraganglia, during embryonic development. Metastases developed and caused the death of two patients 8%. Head and neck paragangliomas hnpgs are rare and highly vascularized tumors, the majority of which are benign. This study compared the results of preoperative octreotide scintigraphy with the histopathology in 21 patients who underwent surgery for presumed head and neck paragangliomas. References to any names, marks, products, or services of third parties or hypertext links to thirdparty sites or information are provided solely as a convenience to you and do.
Carotid body tumor, glomous julgulare tumour, parasympathetic paraganglioma, extra adrenal pheochromocytoma, glomus tumor, chemodectoma, perithelioma, fibroangioma, sympathetic nevi. To the best of our knowledge, no cases of functional pancreatic paragangliomas have been reported in the literature to date. A paraganglioma is a type of tumour that arises from the peripheral nervous system part of the nervous system outside the brain and spinal cord, which is further divided into the. Paragangliomas that form outside the adrenal glands are called extraadrenal paragangliomas. Carotid paragangliomas are tumors developed from chromaffin cells of the extraadrenal tissue.
Know thy enemy from the art of war by sun tzu this is a page of links and information for those with paraganglioma or pheochromocytoma phaeochromocytoma. Paragangliomas with an underlying sdhb mutation are associated in about 30% of the carriers with an aggressive behavior and the development of metastatic disease 11. Download pdf check for updates get permissions abstractexcerpt full text pdf. The main role of pathology was to make a correct diagnosis. A total of 70 patients were identified with 87 cervical paragangliomas.
Most paragangliomas are benign and, as a result, prognosis depends directly on the site of the tumor, the size it may reach and the. Hereditary paragangliomapheochromocytoma genetics home. Also another unique feature was the age of our patient compared to the average reported ages in published literature. Paragangliomas pgs are neuroendocrine tumors derived embryonically from the neural crest cells of the autonomic nervous system. Paragangliomas of the head and neck region polanowski. Paraganglia are clusters of neuroendocrine cells dispersed throughout the body and. And now, its connected to the adobe document cloud. For language access assistance, contact the ncats public information officer. Certain inherited disorders and changes in certain genes increase the risk of pheochromocytoma or. Oct 20, 20 pancreatic paragangliomas are rare tumors, with only 16 reported cases to date. Genetic and rare diseases information center gard po box 8126, gaithersburg, md 208988126 tollfree.
Paragangliomas form in nerve tissue in the adrenal glands and near certain blood vessels and nerves. Operative techniques in orthopaedics paragangliomas. May 11, 2017 the primary cause for paraganglioma is a genetic defect and mutations of certain genes. Paragangliomas are neoplasms that arise from extraadrenal chromaffin cells. They are named for being generally in close proximity to sympathetic ganglia. Some paragangliomas have metastatic abilities and they can produce catecholamines.
Microsurgery of skull base paragangliomas pdf libribook. Laryngeal paragangliomas have the same appearance as paragangliomas of other sites on histopathology. We present two cases of pancreatic paragangliomas with pathological confirmation. Paragangliomas 1 genetic and rare diseases information. This tumor can affect people of any age but most often shows up between the ages of 30 and 50. Head and neck paragangliomas are also referred to as glo mus tumors. While all contain neurosecretory granules, only in % of cases is secretion of hormones such as. Carotid and vagal body paragangliomas internet archive. Extraadrenal paragangliomas are rare tumors that have been reported in many locations, in cluding the kidney, urethra, urinary.
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